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The New England Patriots and Indianapolis Colts rivalry has been the NFL's best since Tom Brady and Peyton Manning first squared off in Week 3 of the 2001 season.

It's been a mostly lopsided rivalry, though, with Brady and the Patriots winning the majority of the regular-season meetings, in addition to a 4-1 mark in the playoffs.

These teams resume their rivalry on Sunday in a Week 6 matchup fans of both teams have had circled on their calendar for months.

In the meantime, let's take a look back into NFL history and view the best moments from the Patriots-Colts rivalry.

Most Memorable Patriots-Colts Moments >>

Thumbnail photo via David Butler II/USA TODAY Sports Images